c70f8c70-a2e1-4cc1-a75f-47ed38fa0881 beie director@blueeyesintelligence.org 10.35940/ijrte.E5206.019521 10.1056/NEJMc1504317DiMasi, J. A., Grabowski, H. G., Hansen, R. W. (2015). The cost of drug development. New England Journal of Medicine, 372(20), 1972- 1972.10.1038/nrd1468Ashburn, T. T., Thor, K. B. (2004). Drug repositioning: identifying and developing new uses for existing drugs. Nature reviews Drug discovery, 3(8), 673-683.Gilbert, J., Henske, P., Singh, A. (2003). Rebuilding big pharma's business model. IN VIVO-NEW YORK THEN NORWALK-, 21(10), 73-80.10.1126/science.1169920Boguski MS et al. Science. 2009 324: 1394 [PMID: 19520944]10.1038/clpt.2009.103Chiang AP Butte AJ, Clin Pharmacol Ther. 2009 86: 507 [PMID: 19571805]10.1371/journal.pone.0028025Yang L Agarwal P, PLoS One. 2012 6: e28025 [PMID: 22205936]10.1371/journal.pcbi.1002503Cheng F et al. PLoS Comput Biol. 2012 8: e1002503 [PMID: 22589709]10.1371/journal.pone.0087864Ye, H., Liu, Q., Wei, J. (2014). Construction of drug network based on side effects and its application for drug repositioning. PloS one, 9(2), e87864.10.1093/bib/bbr013Dudley, J. T., Deshpande, T., Butte, A. J. (2011). Exploiting drug-disease relationships for computational drug repositioning. Brief- ings in bioinformatics, 12(4), 303-311.10.1093/bib/bbv020Li, J., Zheng, S., Chen, B., Butte, A. J., Swamidass, S. J., Lu, Z. (2015). A survey of current trends in computational drug repositioning. Briefings in Bioinformatics, 17(1), 2-12.10.6026/97320630009089Y. Fukuoka, D. Takei, H. Ogawa, A two-step drug repositioning method based on a protein-protein interaction network of genes shared by two diseases and the similarity of drugs, Bioinformation 9 (2013) 089e093.10.1038/nrd1468Ashburn, T. T., Thor, K. B. (2004). Drug repositioning: identifying and developing new uses for existing drugs. Nature reviews Drug discovery, 3(8), 673-683.10.1371/journal.pone.0126082Zhang, M., Luo, H., Xi, Z., Rogaeva, E. (2015). Drug Repositioning for Diabetes Based on'Omics' Data Mining. PloS one, 10(5), e0126082.10.1007/s13311-014-0325-7Kim, T. W. (2015). Drug Repositioning Approaches for the Discovery of New Therapeutics for Alzheimer's Disease. Neurotherapeutics, 12(1), 132-142.10.1038/srep00282Jiang, W., Chen, X., Liao, M., Li, W., Lian, B., Wang, L., ... Li, X. (2012). Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses. Scientific reports, 2.10.1016/j.drudis.2012.07.014Iorio, F., Rittman, T., Ge, H., Menden, M., Saez-Rodriguez, J. (2013). Transcriptional data: a new gateway to drug repositioning?. Drug dis- covery today, 18(7), 350-357.10.1093/bib/bbs082Rukov, J. L., Wilentzik, R., Jaffe, I., Vinther, J., Shomron, N. (2013). Pharmaco-miR: linking microRNAs and drug effects. Briefings in bioin- formatics, bbs082.Okada, Y., Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., ... Graham, R. R. (2014). Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506(7488), 376-381.Ng, C. L. A. R. A., Hauptman, R. U. T. H., Zhang, Y. I. N. L. I. A. N. G., Bourne, P. E., Xie, L. (2014). Anti-infectious drug repurposing using an integrated chemical genomics and structural systems biology approach. InPac Symp Biocomput (Vol. 19, pp. 136-147).10.1038/nature08506Keiser, M. J., Setola, V., Irwin, J. J., Laggner, C., Abbas, A. I., Hufeisen,, S. J., ... Whaley, R. (2009). Predicting new molecular targets for known drugs.Nature, 462(7270), 175-181.10.1109/BIBM.2012.6392722Li, J., Lu, Z. (2012, October). A new method for computational drug repositioning using drug pairwise similarity. In Bioinformatics and Biomedicine (BIBM), 2012 IEEE International Conference On (pp. 1-4). IEEE.10.1039/c3mb70554dTan, F., Yang, R., Xu, X., Chen, X., Wang, Y., Ma, H., ... Jia, X. (2014). Drug repositioning by applying 'expression profiles' generated by integrating chemical structure similarity and gene semantic similarity. Molecular BioSystems, 10(5), 1126-1138.Zheng, C., Guo, Z., Huang, C., Wu, Z., Li, Y., Chen, X., ... Wang,Y. (2015). Large-scale Direct Targeting for Drug Repositioning and Discovery. Scientific reports, 5.10.1371/journal.pcbi.1000423Kinnings, S. L., Liu, N., Buchmeier, N., Tonge, P. J., Xie, L., Bourne, P. (2009). Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. PLoS Comput Biol, 5(7), e1000423.10.1371/journal.pone.0126082Zhang, M., Luo, H., Xi, Z., Rogaeva, E. (2015). Drug Repositioning for Diabetes Based on'Omics' Data Mining. PloS one, 10(5), e0126082.10.1007/s13311-014-0325-7Kim, T. W. (2015). Drug Repositioning Approaches for the Discovery of New Therapeutics for Alzheimer's Disease. Neurotherapeutics, 12(1), 132-142.10.1038/clpt.2009.103Chiang, A. P., Butte, A. J. (2009). Systematic evaluation of drug-disease relationships to identify leads for novel drug uses. Clinical pharmacology and therapeutics, 86(5), 507.10.1371/journal.pcbi.1000662Suthram, S., Dudley, J. T., Chiang, A. P., Chen, R., Hastie, T. J., Butte,J. (2010). Networkbased elucidation of human disease similarities re- veals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol, 6(2), e1000662.10.7717/peerj-cs.46Nugent, T., Plachouras, V., Leidner, J. L. (2016). Computational drug repositioning based on sideeffects mined from social media. PeerJ Computer Science, 2, e46.10.1186/1752-0509-7-S5-S6Wu, C., Gudivada, R. C., Aronow, B. J., Jegga, A. G. (2013). Computational drug repositioning through heterogeneous network clus- tering.BMC systems biology, 7(Suppl 5), S6.