Clinical Study on Atopic Dermatitis and Skin Itchiness Using Cosmetics Containing Palmitoyl Oligopeptide-1, a Skin Penetrating Peptide and Intercellular Lipids
Hoon Cha1, Young Il Kwon2, Su In Park3, Gyu Min An4, Gyu Ri Kim5, Moon Sam Shin6
Manuscript received on 08 May 2019 | Revised Manuscript received on 19 May 2019 | Manuscript Published on 23 May 2019 | PP: 1257-1262 | Volume-7 Issue-6S5 April 2019 | Retrieval Number: F12170476S519/2019©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The purpose of this study was to conduct a clinical trial to improve atopy dermatitis and skin itching caused by dryness using cosmetics containing ceramide precursor (palmitoyl oligopeptide-1), skin penetrating peptide (arginine oligomer peptide, R6) and intercellular lipids (ceramide, cholesterol, essential fatty acid). In this research, skin moisturization measurements (Corneometer), trans-epidermal water loss (TEWL) measurement (Vapometer), researcher visual evaluation (Scoring Atopic Dermatitis, SCORAD, index), visual analog scale (VAS) evaluation (subjective itchiness), and normal photo shoot (DSLR) were used. This study was conducted on 23 adult females with dry skin aged 19~59 years. Clinical results was summarized as followed; 1) skin moisturization value significantly increased 2 and 4 weeks after the products use (p<0.05); 2) TEWL value significantly decreased 2 and 4 weeks after (p<0.05); 3) there was no significant differences of skin pH value 2 and 4 weeks (p<0.05); 4) there was no significant differences of skin temperature value 2 and 4 weeks after (p>0.05); 5) SCORAD Index evaluation value significantly decreased 2 and 4 weeks after (p<0.05); 6) VAS value significantly decreased 2 and 4 weeks after (p<0.05); 7) there was no skin adverse event reported after using the products during the study period. Therefore, the test products (Smato Intensive Calming Cosmetics) containing palmitoyl oligopeptide-1, an epidermal penetrating peptide (R6) and intercellular lipids are considered to have beneficial effects on improvement of atopic dermatitis and skin itchiness caused by skin dryness of 4 weeks use.
Keywords: Atopy Dermatitis, Skin Itchiness, Palmitoyl Oligopeptide-1, Intercellular Lipids, Skin Penetrating Peptide.
Scope of the Article: Bio-Science and Bio-Technology