Size Controlled Synthesis of PHB Micro Particles
Ram Kumar Pandian S1, Sundar K2
1Ram Kumar Pandian S, Department of Biotechnology, Kalasalingam Academy of Research and Education College, Krishnankoil (Tamil Nadu), India.
2Sundar K, Department of Biotechnology, Kalasalingam Academy of Research and Education College, Krishnankoil (Tamil Nadu), India.
Manuscript received on 02 December 2019 | Revised Manuscript received on 20 December 2019 | Manuscript Published on 31 December 2019 | PP: 733-736 | Volume-8 Issue-4S2 December 2019 | Retrieval Number: D11471284S219/2019©BEIESP | DOI: 10.35940/ijrte.D1147.1284S219
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Polymer microparticles are being widely considered for delivery of drugs during therapies, by stabilizing and ensuring biological activity, which facilitates adsorption and delivery of these drugs to the target site. In the present study, size formulation of PHB (polyhydroxybutyrate) microparticles was performed using a 3-factor 2-level Response Surface Methodology (RSM) design. The results were analyzed by DLS measurements. Experimental responses of a total of 20 formulations resulted in various particle sizes ranging between 100nm to ~8000 µm. These size controlled microparticles can be utilized for various therapeutic applications.
Keywords: PHB Micro Particles, RSM, DLS.
Scope of the Article: Bio-Science and Bio-Technology