Prediction of No Tropic Properties of Novel Drug Modafiendz using in-Silico Method
Kumud Pant1, Abhishek Semwal2, Devvret Verma3, Promila Sharma4, Akansha Pal5, Neetu Sharma6, Akshara Pande7, Somya Sinha8, Neema Tufchi9
1Kumud Pant, Department of Biotechnology, Graphic Era Deemed to be University, Dehradun (Uttarakhand), India.
2Abhishek Semwal, Department of Biotechnology, Graphic Era Deemed to be University, Dehradun (Uttarakhand), India.
3Devvret Verma, Department of Biotechnology, Graphic Era Deemed to be University, Dehradun (Uttarakhand), India.
4Promila Sharma, Department of Life Sciences, Graphic Era Deemed to be University, Dehradun (Uttarakhand), India.
5Akansha Pal, Department of Biotechnology, Graphic Era Deemed to be University, Dehradun (Uttarakhand), India.
6Neetu Sharma, Department of Chemistry, Graphic Era (Deemed to be University), Dehradun (Uttarakhand), India.
7Akshara Pande, Department of Computer Science & Engineering, Graphic Era Hill University, Dehradun (Uttarakhand), India.
8Somya Sinha, Department of Biotechnology, Graphic Era Deemed to be University, Dehradun (Uttarakhand), India.
9Neema Tufchi, Department of Biotechnology, Graphic Era Deemed to be University, Dehradun (Uttarakhand), India.
Manuscript received on 15 June 2019 | Revised Manuscript received on 22 June 2019 | Manuscript Published on 01 July 2020 | PP: 1-8 | Volume-8 Issue-2S12 September 2019 | Retrieval Number: B10010982S1219/2020©BEIESP | DOI: 10.35940/ijrte.B1001.0982S1219
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The development and approval of new drug is a tedious, expensive and highly time-consuming task. The demand of new drugs is increasing, and the development of natural drugs and traditional drugs are re-emerging as a new strategic task. The in-silico techniques have boosted the development of potential drug candidates. One important category of drugs is nootropes. It improves the cognitive function, memory, motivation and creativity in healthy individuals. The demand of the nootropic drugs has skyrocketed in past few decades. Modafiendz is a novel drug that is often used by the consumers as it is having similarity in structure and property with modafinil (Nootropic drug). But no major studies have been carried out on this molecule, so remains an investigatory molecule. There are several in-silico techniques that can be used to predict the likeness, metabolic activity and pharmacological property of a molecule. In the current study, realizing the importance of modafiendz, various properties of modafiendz have been predicted like metabolism site, ADME properties, metabolite prediction and DNA adduct formation tendencies.The properties of modafiendz were found to be similar to modafinil in various regards of drug likeability, bioavailability, blood brain permeability (BBB), GI absorption and site of metabolism (SOM). The study suggests modafiendz as a better nootropic drug candidate, when compared to modafinil.
Keywords: No Tropics, Modafinil, Modafiendz, In-Silico Analysis, ADME, DNA Adduct.
Scope of the Article: Regression and Prediction