Formulation of Nanoparticles of Ethanol Extract of Garcinia mangostana L. Leaves as Antioxidant with Pectin as Cross-Linker and Chitosan Variation as Polymer
Diniatik1, Anis Kusumawati2, Agus Siswanto3, Zaim Firdaus Imtihan4, Aji Wahyudi5
1Diniatik, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Central of Java, Indonesia.
2Anis Kusumawati, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Central of Java, Indonesia.
3Agus Siswanto, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Central of Java, Indonesia.
4Zaim Firdaus Imtihan, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Central of Java, Indonesia.
5Aji Wahyudi, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Central of Java, Indonesia.
Manuscript received on 18 October 2019 | Revised Manuscript received on 24 October 2019 | Manuscript Published on 02 November 2019 | PP: 779-783 | Volume-8 Issue-2S9 September 2019 | Retrieval Number: B11620982S919/2019©BEIESP | DOI: 10.35940/ijrte.B1162.0982S919
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: G. mangostana leaves contained xanthone substances, it could be used as antioxidants. Ethanolic extract of G. mangostana leaves were formulated into nanoparticles compound which were made available into nano size through ionic gelation method. G. mangostana leaves were extracted by using maceration method with 50% ethanol as solvent, then were continued with evaporation until thick extract were formed. The nanoparticle formulas were made by mixing G. mangostana extract in ethanol, a solution of chitosan in glacial acetic acid as a polymer, and pectin as a cross-linker solution. There were three formulas (1,2,3) used, with the difference in pectin concentration which were 0.005; 0.01; and 0.02. Characterization of the three formulas include transmittance values were used spectrophotometric method and particle sizes by using particle size analysis (PSA). The results of this research showed that the transmittance of formulations 1, 2 and 3 were 95.9%; 97.7% and 97.3%. The highest transmittance value was formula 3, then were analysed its particle size and zeta potential were 2280 nm and -20.6 mV.
Keywords: G. Mangostana Leaves, Antioxidants, Chitosan, Pectin.
Scope of the Article: Bio-Science and Bio-Technology