Biological Activity of Phenothiazine Sulfonamides
Boggavarapu Jyothia1, Suryadevara Kalpanab2, Nannapaneni Madhavi3
1Boggavarapu Jyothia, Department of Chemistry, Swarna Bharathi Institute of Science and Technology, Khammam (Telangana), India.
2Suryadevara Kalpan, Department of Chemistry, SDMSM Kalasala, Vijayawada (Andhra Pradesh), India.
3Nannapaneni Madhavi, PG, Department of Chemistry, J.K.C College, Guntur (Andhra Pradesh), India.
Manuscript received on 20 August 2019 | Revised Manuscript received on 30 August 2019 | Manuscript Published on 16 September 2019 | PP: 535-537 | Volume-8 Issue-2S6 July 2019 | Retrieval Number: B11020782S619/2019©BEIESP | DOI: 10.35940/ijrte.B1102.0782S619
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Background: Antibacterial activities in “dimethylsulfoxide (DMSO)” were executed by the broth dilution method utilizing nutrient agar. By using the agar cup bioassay method antifungal activities were calculated with “Clotrimazole” as the standard. The novel compounds 1a-j have been evaluated in vitro for their antibacterial activity by “Gram-positive bacteria namely Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus and three Gram-negative bacteria Pseudomonas aeruginosa”, “Klebsiella aerogenes and Chromobacterium violaceum”. All ten compounds were analysed for their antifungal activity against five test “organisms Aspergillus niger, Chrysosporium tropicum, Rhizopus oryzae, Fusarium moniliforme and Curvularia lunata”. Among the isolated compounds 1d and 1e evinced dynamic Movement towards both gram certain What’s more gram negative microscopic organisms. Mixes 1d Also 1f uncovered useful antifungal action. All the secluded compounds were scrutinized for their antibacterial and antifungal activities and most of the compounds manifested remarkable anti bacterial and anti fungal activity.
Keywords: Phenothiazine, Sulfonamide, Antibacterial, Antifungal Activity.
Scope of the Article: Bio-Science and Bio-Technology