Anticancer Effect of Hypophyllanthin, Niranthin and Lintetralin From Phyllanthus amarus on HeLa Cells and NIH/3T3 Cells
Nur Affira Mohd Noor1, Mohd Azlan Nafiah2, Syed Ahmad Tajudin Tuan Johari3, Muhammad Hafiz Husna Hasnan4, Siow-Ping Tan5, Sook Yee Liew6, Unang Supratman7
1Nur Affira Mohd Noor, Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.
2Mohd Azlan Nafiah, Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.
3Syed Ahmad Tajudin Tuan Johari, Faculty of Bioresources and Food Industry, Universiti Sultan Zainal Abidin, Besut Campus, Besut, Kuala Terengganu, Malaysia.
4Muhammad Hafiz Husna Hasnan, Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.
5Siow-Ping Tan, Department of Physical Science, Faculty of Applied Science, Tunku Abdul Rahman University College, Setapak, Kuala Lumpur, Malaysia.
6Sook Yee Liew, Chemistry Division, Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur, Malaysia.
7Unang Supratman, Central Laboratory, Universitas Padjadjaran, Jatinangor, Indonesia.
Manuscript received on 02 August 2019 | Revised Manuscript received on 25 August 2019 | Manuscript Published on 05 September 2019 | PP: 106-110 | Volume-8 Issue-2S7 July 2019 | Retrieval Number: B10240782S719/2019©BEIESP | DOI: 10.35940/ijrte.B1024.0782S719
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Phyllanthus amarus which is locally known as Dukung Anak was one of the herb used in traditional medicine and research of P. amarus in Malaysia was not widely reported. This present research has isolated three chemical compounds and its anticancer effect of this species has been determined. Three lignans namely hypophyllanthin was afforded from hexane crude while niranthin and lintetralin were afforded from ethanol crude. Anticancer test against HeLa cells and NIH/3T3 cells by MTT assays was tested for its anticancer effect. The result shows that hypophyllanthin was considered to possess an active anticancer effect on HeLa cells than NIH/3T3 cells compared to niranthin and lintetralin.
Keywords: Anticancer, HeLa Cells, Lignans, NIH/3T3 Cells and Phyllanthus Amarus.
Scope of the Article: Bio-Science and Bio-Technology