Clinical Efficacy and Safety of an Anti-Cellulite Cosmetics Containing High Content of Caffeine Complex and A Transdermal Penetrating Peptide
Young Il Kwon1, Hoon Cha2, Seon Hwa Kim3, Su In Park4, Moon Sam Shin5, Gyu Ri Kim6
1Young Il Kwon, R&D Center, Dermafirm Co. Ltd., Seongnam, Korea.
2Hoon Cha, R&D Center, Dermafirm Co. Ltd., Seongnam, Korea.
3Seon Hwa Kim, R&D Center, Dermafirm Co. Ltd., Seongnam, Korea.
4Su In Park, Department of Senior Healthcare, Eulji University, Seongnam, Korea.
5Moon Sam Shin, Department of Senior Healthcare, Eulji University, Seongnam, Korea.
6Gyu Ri Kim, Department of Beauty and Cosmetic Science, Eulji University, Seongnam, Korea.
Manuscript received on 08 May 2019 | Revised Manuscript received on 19 May 2019 | Manuscript Published on 23 May 2019 | PP: 1263-1268 | Volume-7 Issue-6S5 April 2019 | Retrieval Number: F12180476S519/2019©BEIESP
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The aim of the study was to examine the clinical efficacy and safety on anti-cellulite cosmetics containing high content caffeine complex (7.0% caffeine; 4.5% mixed hydrotropes; niacinamide and vanillin) anda transdermal penetrating peptide (100ppmarginine oligomer peptide, R6). In this study, dermal and subcutaneous lipid interface length measurement (Skin scanner DUB), skin roughness measurement (PRIMOSⓇ Lite), researcher visual assessment (cellulite grading), thigh normal photo shoot (DSLR) were used. This study was conducted on 23 adult females with cellulite skin aged 20~50 years. As a result of total 22 subjects, excluding 1, used the test product containing a caffeine complex and a skin penetrating peptide 6 weeks in cellulite skin area and clinical results was summarized as followed: 1) the dermis and subcutaneous lipid interface length was statistically significantly decreased after 3 and 6 weeks using the product (p<0.05); 2) the skin roughness value of the thigh was statistically significantly decreased 3 and 6 weeks (p<0.05); 3) the cellulite grades of researcher’s visual evaluation in the thigh area were statistically decreased (p<0.025) after 6 weeks; 4) subjective questionnaire evaluation scores increased significantly (p<0.025) after 3 and 6 weeks; 5) There was no skin adverse event reported after using the product during the study period. Therefore, the test product(JET-Slim Intensive lotion) containing a caffeine complex and a skin penetrating peptide is have beneficial effects in reducing the temporary cellulite in the thigh for 6 weeks.
Keywords: Anti-cellulite, Efficacy, Safety, Caffeine Complex, Transdermal Penetrating Peptide.
Scope of the Article: Bio-Science and Bio-Technology